The arrogant and spiteful President of the Catholic League, Donahue leads those who want to eliminate Snowball and the Hare Club for Men. His efforts bring him to the Vatican, where he double-crosses Stan Marsh and Kyle Broflovski and threatens to kill Snowball. When Jesus appears to thwart Donahue's plans, he orders the boys, Jesus, and Pope Benedict XVI be taken away to the prisons and declares himself Pope. Jesus eventually kills Donahue, though he inexplicably returns to help sue the town of South Park for revenge.
- Donahue referred to Trey Parker and Matt Stone as "whores" an interview after "Cartoon Wars Part II" aired; in the episode "Fantastic Easter Special", he refers to Stan Marsh and Kyle Broflovski by the same phrase.
- Executive Producer Anne Garefino is a Catholic and she has a special resentment for Mr. Donahue.