Tweek is an over-caffeinated 4th grader. His parents own the local coffee shop, which is especially helpful since he drinks coffee to calm down. His parents claim that his hyperactivity is due to ADD.
In Gnomes, Tweek and the The Boys have to do an assignment together. Tweek tells them that Underpants Gnomes steal his underwear at night. He later returns in Tweek vs. Craig in which he fights local trouble-maker Craig Tucker who later becomes his boyfriend in Tweek x Craig. When Kenny dies he becomes a replacement friend for about 5 episodes.
Tweek can be seen with a pet parrot in his room. Next time you see his room there is no sign of a parrot.
Tweek has two known alter egos, Barbarian Tweek and Wonder Tweek, which have both appeared in the South Park games. His alter egos appeared in South Park: The Stick of Truth and South Park: The Fractured but Whole respectively.
When the Asian girls began to draw Yaoi art of Tweek and Craig, rumors of a homosexual relationship between the two sparked. Although the two attempted to dispel it, things got way out of hand; Craig soon became the first person to validate Tweek's abilities, but Tweek accidentally turned their breakup plan into a well-performed lampoon of Craig as a "manipulative cheater". The two ultimately got back together and became an official couple when Craig's dad, Thomas, told Craig that he loves him even if he is gay.
- Gnomes (s02e17; speaking debut)
- Tweek Vs. Craig (s03e04)
- Fourth Grade (s04e12)
- Proper Condom Use (s05e07)
- Osama bin Laden Has Farty Pants (s05e09)
- Professor Chaos (s06e06)
- The Simpsons Already Did It (s06e07)
- Red Hot Catholic Love (s06e08)
- Free Hat (s06e09)
- Bebe's Boobs Destroy Society (s06e10)
- Child Abduction is Not Funny (s06e11)
- The Return of the Fellowship of the Ring to the Two Towers (s06e13)
- The Death Camp of Tolerance (s06e14)
- Red Man's Greed (s07e07)
- Quest for Ratings (s08e11)
- Free Willzyx (s09e13)
- Make Love, Not Warcraft (s10e08)
- Hell on Earth 2006 (s10e11)
- Eat, Pray, Queef (s13e04)
- Informative Murder Porn (s17e02)
- Black Friday (s17e07)
- The Hobbit (s17e10)
- The Cissy (s18e03)
- Tweek x Craig (s19e06)
- Put It Down (s21e02)
Tweek and his Tweek Bros. Coffee Shop played a pretty big role in 2014's video game "South Park: The Stick of Truth".